3/9/2023 0 Comments Michelle cooper musition![]() Thereby affecting the stemness of HSCs ( 11). Ubiquitination, also affect the activation of the Notch1 pathway, Modifications, such as glycosylation, phosphorylation, and InĪddition to the Notch1 receptor itself, its post-translational Particularly T-cell acute lymphoblastic leukemia (T-ALL). Notch1 receptors severely affect the balance of proliferation andĭifferentiation of HSCs which triggers the continuous emergence ofĪbnormal lymphocytes, thus leading to lymphocytic leukemia, Plays a key role in T-cell development and transformation ( 10). Receptor is most closely associated with the stemness of HSCs and Pathway, is essential for the establishment of the earliestĮmbryonic HSCs and is closely associated with the emergence,ĭevelopment, and maintenance of HSCs in adulthood ( 9). HSCs, and that dysregulations of these pathways alone orĬoordinated may lead to the development of leukemia ( 7, 8).Īmong them, Notch signaling, an evolutionarily conserved signaling In recent years, it has been gradually revealed thatĪ series of signaling pathways, such as Wnt, Notch, the TGF-βįamily, Hedgehog and Hippo signaling, could affect the stemness of Insight into HSCs and hope for a cure for leukemia. Understanding of the signaling pathways or regulatory factors thatĪre capable of regulating the stemness of HSCs may provide further (CML) and chronic lymphoblastic leukemia (CLL). Subtypes of leukemia include acute myelogenous leukemia (AML),Īcute lymphoblastic leukemia (ALL), chronic myelogenous leukemia Occurs and further abnormal blood system tumors are produced, Stemness of HSCs is destroyed, abnormal production of blood cells HSCs helps maintain the homeostasis of the blood system byīalancing the proliferation and differentiation of HSCs. Produce differentiated cells (such as lymphocytes and granulocytes)Īnd to interact with the hematopoietic microenvironment to maintainĪ balance between quiescence, proliferation, and regeneration HSCs combines the ability of the HSCs to perpetuate its lineage, to Homeostasis by self-renewal or differentiation into all blood cell Eventually, USCs may form only one cell type, suchĪmong multipotent stem cells, HSCs are the mostĬommon multipotent stem cells with the ability to maintain ![]() Marrow stem cells which may develop into white blood cells but not ![]() OSCs can differentiate into numerous cell types, such as bone Hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), and The majority of adult stem cells are multipotent, including Multipotent stem cells can produce certain lineages of cells, and Outside the embryo, and embryonic stem cells are a prime example. Layers, with the exception of the cells that form structures Potential, able to produce an entire living organism on their own,Īnd most notably a zygote. Into five groups: Totipotent stem cells (TSCs), pluripotent stemĬells (PSCs), multipotent stem cells, oligopotent stem cells (OSCs)Īnd unipotent stem cells (USCs) ( 2). In vivo and differentiate into mature specialized cells Stem cells are undifferentiated cells that have theĪbility to proliferate (self-renewal) both in vitro and In addition, the association between abnormal HSCs mediated by Notch1 or ubiquitinated Notch1and T‑cell acute lymphoblastic leukemia (T‑ALL) was also examined, which provides a promising direction for clinical application. In the present review, the association between Notch1 and HSCs and the link between the ubiquitination modification of Notch1 and HSCs were described. In addition, it may aid in identifying potential therapeutic targets for specific leukemias and provide potential prognostic indicators for HSC transplantation (HSCT). Therefore, a detailed elucidation of Notch1 and its ubiquitination modification may help to improve understanding of the maintenance of HSC properties and the pathogenesis of leukemia. In recent decades, the ubiquitination modification of Notch1 has been gradually revealed, and also demonstrated to affect the proliferation and differentiation of HSCs. ![]() Notch1, a key receptor in the Notch signaling pathway, plays an important regulatory role in these properties of HSCs, particularly in the maintenance of the stemness of HSCs. Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self‑renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia.
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